Synergistic tumor microenvironment targeting and blood-brain barrier penetration via a pH-responsive dual-ligand strategy for enhanced breast cancer and brain metastasis therapy

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Figure 4

(A) The in vivo imaging of 4T1&NIH 3T3 tumor-bearing mice after intravenous injection of DiD-labeled liposomes at 4 h, 8 h and 24 h, respectively. (B) The images of ex vivo tumors of mice at 24 h after injection of DiD-labeled liposomes. (C) The average fluorescence intensity of isolated tumors of mice at 24 h after injection of DiD-labeled liposomes (mean ± SD, n = 3, *p< 0.05, **p < 0.01). (D) The distribution of DiD-labeled liposomes in tumor sections. Blue, nucleus; FITC, folate receptor; DiD, DiD-labeled liposomes. Scar bar, 100 μm.



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