Nanofiber technology in the ex vivo expansion of cord blood-derived hematopoietic stem cells


Fig. 1

Schematic for the bone marrow hematopoietic stem cell (HSC) niche. The HSC niche is a highly specialized and complex compartment that includes a variety of cells including HSC, mesenchymal stromal cells (MSC), fibroblasts, adipocytes, osteoblasts, osteoclasts, macrophages, endothelial cells, Cxcl-12-abundant reticular (CAR) cells, nerve cells and others. This cellular complexity is linked to a variety of cytokines and growth factors, chemokines and proteases that are present within this micromilieu. Structurally, the HSC niche is divided into the endosteal niche, where HSC are mostly quiescent under hypoxia and high Ca2+ levels, and the vascular niche, where HSC under normoxia and decreased Ca2+ levels can proliferate, differentiate and enter the peripheral circulation.

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